Mineralocorticoid Receptors

Supporting information

Mineralocorticoid receptors (MRs) are nuclear hormone receptors of the NR3C class, which also includes androgen, progesterone and glucocorticoid receptors. They can exist as homo- or heterodimers and are coupled to Hsp90 or HMGB proteins. The major signaling pathway used by MRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

To view external sources of pharmacological information for Mineralocorticoid Receptors, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human NR3C2 NM_000901 P08235
Mouse Nr3c2 NM_001083906 Q8VII8
Rat Nr3c2 NM_013131 P22199

Literature for Mineralocorticoid Receptors

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