Glucocorticoid Receptors

Supporting information

Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by GRs is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT.

GRs are ubiquitously expressed and mediate a vast array of physiological functions. Glucocorticoids regulate carbohydrate, protein and fat metabolism, modulate immune responses through supression of chemokine and cytokine production and have critical roles in constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. The human gene encoding the glucocorticoid receptor has been localized to 5q31-q32.

To view external sources of pharmacological information for Glucocorticoid Receptors, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human NR3C1 NM_001020825 P04150
Mouse Nr3c1 NM_008173 P06537
Rat Nr3c1 NM_012576 P06536

Literature for Glucocorticoid Receptors

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