NK3 Receptors

Supporting information

The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery.

NK3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P (NKB > NKA > SP). The human gene encoding the NK3 receptor has been localized on chromosome 4 (4q25).

To view external sources of pharmacological information for NK3 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human TACR3 NM_001059 P29371
Mouse Tacr3 NM_021382 P47937
Rat Tacr3 NM_001059 P29371

Literature for NK3 Receptors

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