GTPases are a group of enzymes that catalyze hydrolysis of the γ phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.
There are six main groups of GTPases; heterotrimeric G protein GTPases (E.C. 184.108.40.206), small monomeric GTPases (E.C. 220.127.116.11), protein-synthesizing GTPases (E.C. 18.104.22.168), signal-recognition-particle GTPase (E.C. 22.214.171.124), dynamin GTPases (E.C. 126.96.36.199) and tubulin GTPases (E.C. 188.8.131.52).View all products for GTPases »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|Rho GTPase 1||Human||ARHGAP1||NM_004308||Q07960|
|Rho GTPase 4||Human||ARHGAP4||NM_001666||P98171|
|View all GTPase Gene Data »|