GTPases

Supporting information

GTPases are a group of enzymes that catalyze hydrolysis of the γ phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.

There are six main groups of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1), small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing GTPases (E.C. 3.6.5.3), signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C. 3.6.5.6).

View all products for GTPases »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Rho GTPase 1 Human ARHGAP1 NM_004308 Q07960
Mouse Arhgap1 NM_146124 Q5FWK3
Rat Arhgap1 NM_001107747 XP_230284
Rho GTPase 4 Human ARHGAP4 NM_001666 P98171
Mouse Arhgap4 NM_138630 NP_619536
Rat Arhgap4 NM_144740 Q8K4G7
View all GTPase Gene Data »

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