Aldose Reductase

Supporting information

Aldose reductase (also known as aldehyde reductase) catalyzes the reduction of a wide variety of hydrophobic and hydrophilic carbonyl-containing compounds to their corresponding alcohols. This enzyme is cytosolic, exists as a monomer and requires NADPH as a co-factor. Aldose reductase catalyzes the rate-limiting step of the polyol pathway (the conversion of glucose to sorbitol), a pathway that is overactive in diabetes mellitus and the cause of diabetic complications.

Aldose reductase is expressed in most mammalian tissues and is found at high concentrations in the seminal vesicles, lens, retina, renal medulla and sciatic nerve. Currently there is much interest in the development of pharmalogical inhibitors targeting this enzyme as a method of preventing the complications associated with chronic hyperglycemia.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human AKR1B1 NM_001628 P15121
Mouse Akr1b3 NM_009658 P45376
Rat Akr1b1 NM_012498 P07943

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