Urotensin-II Receptors

Supporting information

The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels.

The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation. The human gene encoding the UT receptor is located on chromosome 17q25.3.

To view external sources of pharmacological information for Urotensin-II Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human UTS2R NM_018949 Q9UKP6
Mouse Uts2r NM_145440 Q8VIH9
Rat Uts2r NM_020537 P49684

Literature for Urotensin-II Receptors

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

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Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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