Ketamine and Metabolites

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More Information »Ketamine is a water soluble phencyclidine derivative with an asymmetric carbon atom; it has two enantiomers. Ketamine is metabolized in the liver via N-demethylation and ring hydroxylation pathways and the main metabolites are norketamine and its hydroxylated derivatives.

Ketamine and Metabolite Products

 
Cat.No.
Product Name / Activity
6094 2R,6R-Hydroxynorketamine hydrochloride
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
6095 2S,6S-Hydroxynorketamine hydrochloride
Decreases D-serine (a NMDA co-agonist); antidepressant
5982 cis-6-Hydroxynorketamine hydrochloride
Enhances AMPA currents: antidepressant
3131 Ketamine hydrochloride
Non-competitive NMDA receptor antagonist
4379 (S)-(+)-Ketamine hydrochloride
NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective.
1970 Norketamine hydrochloride
Potent, non-competitive NMDA antagonist; antinociceptive
5996 (R)-Norketamine hydrochloride
NMDA receptor modulator; analgesic
6112 (S)-Norketamine hydrochloride
NMDA receptor modulator; analgesic
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