TRPV

Supporting information

Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and six members (TRPV1-6) have so far been identified.

The six vanilloid receptor members have been divided into four groups on the basis of structure and function: TRPV1/2, TRPV3, TRPV4 and TRPV5/6. TRPV1-4 are thermosensitive, non-selective cation channels that exist as tetrameric complexes. They are activated by a range of stimuli including heat, protons, lipids and changes in osmolarity or pressure. TRPV5-6 are calcium selective channels that are involved in the absorption and reabsorption of calcium across intestinal and renal epithelia.

It has been proposed that cannabinoids are endogenous ligands for vanilloid receptors. Furthermore, adenosine has been shown to be an endogenous TRPV1 ligand and TRPV4 is activated by anandamide and arachidonic acid (Cat. No. 2756).

To view external sources of pharmacological information for TRPV, please click here: IUPHAR Receptor Code and BJP Guide

View all products for TRPV »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPV1 Human TRPV1 NM_018727 Q8NER1
Mouse Trpv1 NM_001001445 Q704Y3
Rat Trpv1 NM_031982 O35433
TRPV2 Human TRPV2 NM_016113 Q9Y5S1
Mouse Trpv2 NM_011706 Q9WTR1
Rat Trpv2 NM_017207 Q9WUD2
View all TRPV Gene Data »

Literature for TRPV

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.

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Pain Life Science Poster

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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