Lipoxygenases

Supporting information

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound.

Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

To view external sources of pharmacological information for Lipoxygenases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
5-LOX Human ALOX5 NM_000698 P09917
Mouse Alox5 NM_009662 P48999
Rat Alox5 NM_012822 P12527
12R-LOX Human ALOX12B NM_001139 O75342
Mouse Alox12b NM_009659 O70582
Rat Alox12b NM_001039377 Q2KMM4
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Literature for Lipoxygenases

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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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Immunology Product Listing

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Immunology Guide

Immunology Product Listing

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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