Inositol Lipids

Supporting information

Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3).

In response to GPCR and receptor tyrosine kinase activation, PI 3-kinase phosphorylates some inositol lipids, such as PI(3,4,5)P3, and PLC mediates inositol lipid cleavage to generate further second messengers such as DAG and IP3. IP3 subsequently acts upon IP3 receptors located in the ER membrane and mediates Ca2+ release.

Regulation of inositol lipid signaling pathways is through phosphorylation (e.g. by inositol-tetrakisphosphate 1-kinase) and dephosphorylation (e.g. by inositol monophosphatase (IMPase)) of inositol lipids. This large group of proteins constitute a major intracellular signal transduction network. Because of this, inositol lipids are involved in a vast number of physiological processes.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IMPase 1 Human IMPA1 NM_005536 P29218
Mouse Impa1 NM_018864 O55023
Rat Impa1 NM_032057 P97618
IMPase 2 Human IMPA2 NM_014214 O14732
Mouse Impa2 NM_053261 Q91UZ5
Rat Impa2 NM_172224 Q8CIN7
View all Inositol Lipid Signaling Pathway Gene Data »

Literature for Inositol Lipids

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