Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3).
In response to GPCR and receptor tyrosine kinase activation, PI 3-kinase phosphorylates some inositol lipids, such as PI(3,4,5)P3, and PLC mediates inositol lipid cleavage to generate further second messengers such as DAG and IP3. IP3 subsequently acts upon IP3 receptors located in the ER membrane and mediates Ca2+ release.
Regulation of inositol lipid signaling pathways is through phosphorylation (e.g. by inositol-tetrakisphosphate 1-kinase) and dephosphorylation (e.g. by inositol monophosphatase (IMPase)) of inositol lipids. This large group of proteins constitute a major intracellular signal transduction network. Because of this, inositol lipids are involved in a vast number of physiological processes.View all products for Inositol Lipids »
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Literature for Inositol Lipids
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