Inositol Lipids

More Information »Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Inositol lipid signaling pathways are regulated by phosphorylation.

Inositol Lipid Products

Antagonists
Cat.No.
Product Name / Activity
1224 2-APB
IP3 receptor antagonist. Also TRP channel modulator
4168 PIT 1
PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling
Inhibitors
Cat.No.
Product Name / Activity
3578 AS 605240
Potent and selective PI 3-kinase γ (PI 3-Kγ) inhibitor
4839 AZD 6482
Potent and selective PI 3-Kβ inhibitor
3606 BAG 956
Dual PI 3-kinase and PDPK1 (PDK1) inhibitor
4674 CZC 24832
Selective inhibitor of PI 3-kinase γ
1420 D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
Potent inhibitor of Ins(1,4,5)P3 5-phosphatase. Metabolite of Cat. No. 1482
0682 L-690,488
Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
0681 L-690,330
Inositol monophosphatase inhibitor
1130 LY 294002 hydrochloride
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
2418 LY 303511
Negative control of LY 294002 (Cat. No. 1130)
3977 3-Methyladenine
Class III PI 3-kinase inhibitor; also inhibits autophagy
2930 PI 103 hydrochloride
Inhibitor of PI 3-kinase, mTOR and DNA-PK
2814 PI 828
PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
1125 Quercetin
Non-selective PI 3-kinase inhibitor
3946 TNP
Inhibitor of IP6K; also inhibits IP3K
1232 Wortmannin
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
Activators
Cat.No.
Product Name / Activity
1983 740 Y-P
Cell-permeable PI 3-kinase activator
Other
Cat.No.
Product Name / Activity
1482 D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
Ca2+ mobilizing second messenger
1042 N-Methyllidocaine iodide
Enhances biosynthesis of phosphatidylinositol
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