Phosphodiesterases

Supporting information

Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation.

There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

To view external sources of pharmacological information for Phosphodiesterases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PDE1A Human PDE1A NM_005019 Q9C0L4
Mouse Pde1a NM_016744 Q61481
Rat Pde1a NM_030871 Q9EPR9
PDE1B Human PDE1B NM_000924 Q01064
Mouse Pde1b NM_008800 Q01065
Rat Pde1b NM_022710 Q01066
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Literature for Phosphodiesterases

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