More Information »Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Phosphodiesterase Products

Product Name / Activity
2432 Anagrelide hydrochloride
Potent PDE3 inhibitor
4496 BC 11-38
Selective PDE11 inhibitor
2237 BRL 50481
Selective PDE7 inhibitor
2793 Caffeine
Cyclic nucleotide PDE inhibitor
4420 Carbazeran citrate
Aldehyde oxidase substrate; PDE inhibitor
3936 CDP 840 hydrochloride
Potent and selective PDE4 inhibitor
2344 CGH 2466 dihydrochloride
Anti-inflammatory agent. Inhibitor of PDE4 and p38 MAPK, also adenosine receptor antagonist
0915 Cilostamide
PDE3 inhibitor
1692 Cilostazol
PDE3A inhibitor. Also adenosine uptake inhibitor
2729 CP 80633
Selective PDE4 inhibitor
0691 Dipyridamole
PDE5/6/8/10/11 inhibitor
5695 Eggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
1261 EHNA hydrochloride
PDE2 inhibitor
1693 Enoximone
PDE3 inhibitor
0438 Etazolate hydrochloride
PDE4 inhibitor
4165 Gisadenafil besylate
Potent PDE5 inhibitor; orally bioavailable
2845 IBMX
PDE inhibitor (non-selective)
1694 Ibudilast
PDE inhibitor (non-selective)
1816 ICI 63197
PDE4 inhibitor
2504 Irsogladine maleate
PDE4 inhibitor; antiulcer agent
1436 MDL 12330A hydrochloride
Cyclic nucleotide PDE inhibitor; also adenylyl cyclase inhibitor
3053 Mesopram
Orally active PDE4 inhibitor
1504 Milrinone
PDE3 inhibitor
0552 MMPX
PDE1 inhibitor
0432 MY-5445
PDE5 inhibitor
3056 Pentoxifylline
PDE inhibitor
5915 PF 04449613
Potent PDE9 inhibitor; brain penetrant
4525 Piclamilast
Potent and selective PDE4 inhibitor
0415 Ro 20-1724
PDE4 inhibitor
0905 Rolipram
PDE4 inhibitor
1349 (R)-(-)-Rolipram
PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
1350 (S)-(+)-Rolipram
PDE4 inhibitor. Less active enantiomer of rolipram (Cat. No. 0905)
3315 RS 25344 hydrochloride
Potent PDE4 inhibitor
1148 Siguazodan
PDE3 inhibitor
3784 Sildenafil citrate
Orally active, potent PDE5 inhibitor
1676 T 0156 hydrochloride
Highly potent, selective PDE5 inhibitor
4572 TC-E 5005
Potent and selective PDE10A inhibitor
2795 Theophylline
Phosphodiesterase inhibitor
2337 Trequinsin hydrochloride
Extremely potent inhibitor of PDE3
0757 Vinpocetine
PDE1 inhibitor
1821 YM 976
PDE4 inhibitor
0947 Zaprinast
PDE5/6/9/11 inhibitor
1046 Zardaverine
PDE3/4 inhibitor
Ligand Sets
Product Name / Activity
1881 Phosphodiesterase Inhibitor Tocriset™
Selection of 5 phosphodiesterase inhibitors (Cat. Nos. 0915, 1504, 0415, 1349 and 1046)
Product Name / Activity
5424 Deltarasin
High affinity PDEδ-KRAS interaction inhibitor

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