Adenylyl Cyclases

Supporting information

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testes.

To view external sources of pharmacological information for Adenylyl Cyclases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AC1 Human ADCY1 NM_021116 Q08828
Mouse Adcy1 NM_009622 O88444
Rat Adcy1 XM_223616 XP_223616
AC2 Human ADCY2 NM_020546 Q08462
Mouse Adcy2 NM_153534 Q80TL1
Rat Adcy2 NM_031007 P26769
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Literature for Adenylyl Cyclases

Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

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Schizophrenia Life Science Poster

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Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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