Calcium-Sensitive Protease Modulators

Supporting information

Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. These include remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation.

Cathepsins are lysosomal calcium-sensitive proteases that have a key role in cellular protein turnover. This group of proteases includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) and cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes. These include maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, osteo- and rheumatoid arthritis, and atherosclerosis.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Calpain 1 Human CAPN1 NM_005186 P07384
Mouse Capn1 NM_007600 O35350
Rat Capn1 NM_019152 P97571
Calpain 2 Human CAPN2 NM_001748 P17655
Mouse Capn2 NM_009794 O08529
Rat Capn2 NM_017116 Q07009
View all Calcium Sensitive-Protease Gene Data »

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