Calcium Binding Protein Modulators

Supporting information

Calcium binding proteins act to regulate the concentration of Ca2+ available as a second messenger in a vast array of signaling cascades. The most common calcium binding protein is calmodulin. Calmodulin is expressed in all eukaryotic cells and can be found in the cytoplasm, within organelles or associated with the plasma membrane. Each calmodulin protein can bind four Ca2+ ions and functions to sequester Ca2+ ions, thus effecting intracellular signaling.

Ca2+/calmodulin-dependent protein kinases (CaMKs) are serine/threonine kinases that mediate many of the second messenger effects of Ca2+. They are activated by calmodulin and Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) in response to rises in intracellular Ca2+ levels. They influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal reorganization and learning and memory. Myosin light chain kinase (MLCK) is a specific CaMK involved in muscle contraction. MLCKs are activated by Ca2+-calmodulin complexes and require Ca2+ as a cofactor.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Calmodulin 1 Human CALM1 NM_006888 P62158
Mouse Calm1 AK162314 P62204
Rat Calm1 NM_031969 P62161
Calmodulin 2 Human CALM2 NM_001743 P62158
Mouse Calm2 AK002974 P62204
Rat Calm2 NM_017326 P62161
View all Calcium Binding Protein Gene Data »

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