σ1 Receptors

More Information »σ1 receptors are members of the σ family of receptors that also includes σ2 receptors. They are distinguished from σ2 receptors as they have high affinity and stereoselectivity for the (+)-isomers of pentazocine, SK&F 10047 and cyclazocine, and different subcellular localizations.

σ1 Receptor Products

Agonists
Cat.No.
Product Name / Activity
3870 (±)-PPCC oxalate
Selective sigma (σ) agonist (σ1> σ2)
0589 PRE-084 hydrochloride
Highly selective σ1 agonist
4951 SA 4503 dihydrochloride
Selective σ1 receptor agonist
1079 (+)-SK&F 10047 hydrochloride
σ1 selective agonist
Antagonists
Cat.No.
Product Name / Activity
0956 BD 1047 dihydrobromide
σ1 selective antagonist
3133 NE 100 hydrochloride
Selective σ1 antagonist
Ligands
Cat.No.
Product Name / Activity
0883 BD 1063 dihydrochloride
Selective σ1 ligand, putative antagonist
0454 Carbetapentane citrate
High affinity σ1 ligand
3428 DMT
Endogenous σ1 ligand. Also 5-HT2A agonist
2195 Eliprodil
σ ligand (σ1 > σ2). Also polyamine site NMDA antagonist and Ca2+ channel blocker. Neuroprotective
1033 Fluvoxamine maleate
High affinity σ1 ligand
0931 Haloperidol hydrochloride
High affinity σ ligand (σ1 > σ2). Also D2 antagonist
0748 4-IBP
σ ligand, σ1 > σ2
2332 (+)-Igmesine hydrochloride
Selective σ1 ligand; antidepressant
2606 PD 144418 oxalate
High affinity, selective σ1 ligand
0763 N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide
σ1 selective ligand
2669 TC 1
High affinity σ1 ligand
Other
Cat.No.
Product Name / Activity
2074 SKF 83959 hydrobromide
Potentiates agonist binding of the σ1 receptor. Also D1-like agonist
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