5-HT Transporters

Supporting information

5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move one or more molecules per cycle.

Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini, putative phosphorylation sites acting as potential targets for PKA and PKC and regions essential for 5-HT selective affinity. There is evidence to suggest that SERTs are linked to neuroticism, sexual behavior, alcoholism, clinical depression, hypertension and obsessive-compulsive disorder.

To view external sources of pharmacological information for 5-HT Transporters, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human SLC6A4 NM_001045 P31645
Mouse Slc6a4 NM_010484 Q60857
Rat Slc6a4 NM_013034 P31652

Literature for 5-HT Transporters

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Request copy | Download PDF | View all Product Guides & Listings
Neurodegeneration Product Guide
5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Request copy | Download PDF | View all reviews
5-HT Receptors Scientific Review

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Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

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5-HT Scientific Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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