Purinergic (P2X) Receptors

Supporting information

P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini.

Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility, nociception and immune response. In particular P2X7 receptors are of interest in cancer immunology as they are oxerexpressed in tumors. Elevated intratumoral ATP levels acting via P2X7 receptors on myeloid-derived suppressor cells (MDSCs), result in immunosuppression.

To view external sources of pharmacological information for Purinergic (P2X) Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Purinergic (P2X) Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
P2X1 Human P2RX1 NM_002558 P51575
Mouse P2rx1 NM_008771 P51576
Rat P2rx1 NM_012997 P47824
P2X2 Human P2RX2 NM_174873 Q9NR38
Mouse P2rx2 NM_153400 NP_700449
Rat P2rx2 NM_053656 P49653
View all P2X Receptor Gene Data »

Literature for Purinergic (P2X) Receptors

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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Cardiovascular Research Product Guide
Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
P2X and P2Y Receptors Scientific Review

A review of the subtypes and structures of P2 receptor families and the pharmacological probes used to study them. Compounds available from Tocris are listed.

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P2X and P2Y Receptors Scientific Review
Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.

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Pain Life Science Poster

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

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Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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