PACAP Receptors

Supporting information

Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2.

PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.

To view external sources of pharmacological information for PACAP Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADCYAP1R1 NM_001118 P41586
Mouse Adcyap1r1 NM_007407 P70205
Rat Adcyap1r1 NM_133511 P32215

Literature for PACAP Receptors

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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

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