NPY Receptors

Supporting information

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.

All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

To view external sources of pharmacological information for NPY Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for NPY Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Y1 Human NPY1R NM_000909 P25929
Mouse Npyr1 NM_010934 Q04573
Rat Npy1r NM_001013032 P21555
Y2 Human NPY2R NM_000910 P49146
Mouse Npy2r NM_008731 P97295
Rat Npy2r NM_023968 O70424
View all Neuropeptide Y Receptor Gene Data »

Literature for NPY Receptors

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Request copy | Download PDF | View all Product Guides & Listings
GPCR Product Listing
Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Request copy | Download PDF | View all Product Guides & Listings
Peptide Hormone Receptors Product Listing
Peptides Involved in Appetite Modulation Scientific Review

A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis, outlining the putative roles of most of the known proteins and lists compounds available from Tocris.

Download PDF | View all reviews
Peptides Involved in Appetite Modulation Scientific Review
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Request copy | View all posters
Cardiovascular Life Science Poster
Gut Hormones Life Science Poster

Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.

Request copy | View all posters
Gut Hormones Life Science Poster

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

Gut Hormones Life Science Poster

Our Gut Hormones and the Regulation of Appetite poster gives an overview of the neuropeptide modulators and gut hormones that influence appetite. Request copy today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.