CRF Receptors

Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

CRF Receptor Target Files

Related Categories

The tables below summarizes the properties of these receptors and include examples of selective ligands available from Tocris.

Receptor Subtype CRF1 CRF2a CRF2b
Transduction Mechanism Activates Gs Activates Gs Activates Gs

Key Compounds Ki (nM)
Agonists CRF (human, rat) (1151)
Urocortin (rat) (1605)
Sauvagine (1609)
Stressin I (1608)
11
13
9.4
1.5
44
1.5
9.9
224
38
0.97
3.8
224
Antagonists Astressin (1606)
α-helical CRF 9-41 (1184)
NBI 27914 (1591)
CP 154526 (2779)
CP 376395 (3212)
K 41498 (2070)
2
17
2
2.7
12
425
1.5
5
> 10000
> 10000
> 10000
0.66
1
0.97
-
> 10000
> 10000
0.62

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