Calcitonin and Related Receptors

Supporting information

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid.

The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension. The CGRP receptor has also recently been implicated in the pathogenesis of migraine

To view external sources of pharmacological information for Calcitonin and Related Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CT Human CALCR NM_001742 P30988
Mouse Calcr NM_007588 Q60755
Rat Calcr NM_053816 P32214
CALCRL Human CALCRL NM_005795 Q16602
Mouse Calcrl NM_018782 Q9R1W5
Rat Calcrl NM_012717 Q63118
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