Amyloid β Peptide Inhibitors

Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
γ-secretase inhibitor; reduces Aβ levels
4924 CEP 1347
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
3360 CGP 52411
Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442 CGP 53353
Inhibitor of de novo Aβ42 assembly
2654 Compound W
γ-secretase inhibitor; reduces Aβ42 levels
2634 DAPT
γ-secretase inhibitor; reduces Aβ42 levels
4524 EGCG
Inhibits formation of amyloid fibrils
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
5398 NQTrp
Potent inhibitor of Aβ oligomer and fibril formation
5751 PF 3084014 hydrobromide
Potent γ-secretase inhibitor
2408 Ro 90-7501
Inhibitor of Aβ42 fibril formation
4699 SEN 1269
Amyloid-β aggregation inhibitor
4426 Tanshinone IIA
Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding

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Neurodegeneration Product Guide

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Alzheimer's Life Science Poster

Written by Alan Palmer

Alzheimer's Life Science Poster

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