NOP Receptors

Supporting information

The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.

The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

To view external sources of pharmacological information for NOP Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human OPRL1 NM_000913 P41146
Mouse Oprl1 NM_011012 P35377
Rat Oprl1 NM_031569 P35370

Literature for NOP Receptors

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