δ Opioid Receptors

Supporting information

The δ opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes μ, κ and NOP receptors. In the CNS, δ opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem.

δ opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the δ opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).

To view external sources of pharmacological information for δ Opioid Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human OPRD1 NM_000911 P41143
Mouse Oprd1 NM_013622 P32300
Rat Oprd1 NM_012617 P33533

Literature for δ Opioid Receptors

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