iNOS

Supporting information

Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active. Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required for catalytic activity.

iNOS gene expression is regulated by various pathways including NF-κB, IFN-γ (signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-β and interleukins -4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS homodimerization by NAP110.

iNOS has roles in the innate immune system and displays antibacterial, antiviral and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human NOS2 NM_000625 P35228
Mouse Nos2 NM_010927 P29477
Rat Nos2 NM_012611 Q6XS76

Literature for iNOS

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