Supporting information

Endothelial nitric oxide synthase (eNOS), along with inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. It is activated at concentrations of calcium greater than 100 nM and requires tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity.

eNOS is tightly regulated by co- and post-translational lipid modifications, phosphorylation by Akt/PKB, PKA and AMPK and protein-protein interactions. Negative protein-protein interactions are mediated by Hsp90 and Cav-1 in the Golgi and by NOSIP and NOSTRIN at the plasma membrane, whilst dynamin, porin and soluble guanylyl cyclase are positive regulators of eNOS activity.

eNOS is a critical mediator of cardiovascular homeostasis through regulation of the diameter of blood vessels and maintenance of an antiproliferative and antiapoptotic environment in the vasculature. The human gene encoding eNOS is localized to chromosome 7q36.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human NOS3 NM_000603 P29474
Mouse Nos3 NM_008713 P70313
Rat Nos3 NM_021838 Q9Z1P9

Literature for eNOS

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