Voltage-gated Sodium (NaV) Channels

Supporting information

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Structurally, NaV channels are composed of one pore-forming α-subunit, which may be associated with either one or more β-subunits. α-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

To view external sources of pharmacological information for Voltage-gated Sodium (NaV) Channels, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Voltage-gated Sodium (NaV) Channels »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NaV1.1 Human SCN1A NM_006920 P35498
Mouse Scn1a NM_018733 NP_061203
Rat Scn1a NM_030875 P04774
NaV1.2 Human SCN2A NM_021007 Q99250
Mouse Scn2a1 NM_001099298 NP_001092768
Rat Scn2a1 NM_012647 P0477
View all NaV Gene Data »

Literature for Voltage-gated Sodium (NaV) Channels

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