Voltage-gated Calcium Channels (CaV)

Supporting information

Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

Voltage-gated calcium channels are formed from four or five distinct subunits; the α-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activated dihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Cav1.1 Human CACNA1S NM_000069 Q13698
Mouse Cacna1s NM_001081023 Q02789
Rat Cacna1s NM_053873 Q02485
Cav1.2 Human CACNA1C NM_000719 Q6PKM7
Mouse Cacna1c NM_009781 Q01815
Rat Cacna1c NM_012517 Q8VHT3
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