I1 Receptors

Supporting information

Imidazoline 1 receptors (I1) (labeled by clonidine) are members of the imidazoline family of receptors, which also include I2 (labeled by idazoxan) and I3 receptors. I1 receptors are localized to the plasma membrane and are found in the lateral reticular nucleus, locus coeruleus, kidney, pancreas and on platelets.

I1 activation is coupled to choline phospholipid hydrolysis, leading to the generation of diacylglyceride, arachidonic acid and eicosanoids. Also, I1 may inhibit the Na+,H+ exchanger.

Physiological roles of the I1 receptor include lowering blood pressure, renal osmolar clearance, central control of intraocular pressure and the electrophysiological response to hypoxia.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human NISCH NM_007184 Q9Y2I1
Mouse Nisch NM_022656 Q80TM9
Rat Nisch XM_240330 Q4G017

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