Histamine H3 Receptors

More Information »Histamine H3 receptors are Gαi/o-protein-coupled receptors expressed at high levels on histaminergic neurons in the CNS, particularly in the basal ganglia, cortex and hippocampus. H3 receptors are thought to function as presynaptic autoreceptors.

Histamine H3 Receptor Products

Agonists
Cat.No.
Product Name / Activity
3545 Histamine dihydrochloride
Endogenous histamine receptor agonist
0729 Imetit dihydrobromide
Standard H3 and H4 agonist (H3 > H4)
0932 Immepip dihydrobromide
Standard H3 agonist. Also H4 agonist
2315 Immethridine dihydrobromide
Potent H3 agonist, highly selective over H4
2947 Methimepip dihydrobromide
Extremely selective H3 agonist
0569 (R)-(-)-α-Methylhistamine dihydrobromide
Potent, standard H3 agonist
0572 (S)-(+)-α-Methylhistamine dihydrobromide
H3 agonist, less active enantiomer
0573 Nα-Methylhistamine dihydrochloride
Non-selective H3 agonist
2477 Proxyfan oxalate
High affinity H3 ligand
Antagonists
Cat.No.
Product Name / Activity
4697 A 331440 dihydrochloride
Selective H3 antagonist
3743 BF 2649 hydrochloride
H3 receptor inverse agonist/antagonist
2211 Carcinine ditrifluoroacetate
Highly selective H3 antagonist
0752 Clobenpropit dihydrobromide
Highly potent H3 antagonist and H4 partial agonist
2409 Conessine
Potent and selective H3 receptor antagonist
2419 GT 2016
Selective H3 antagonist
1858 Impentamine dihydrobromide
Selective H3 antagonist
0779 Iodophenpropit dihydrobromide
Potent, selective H3 antagonist
4019 JNJ 10181457 dihydrochloride
H3 antagonist
4020 JNJ 5207852 dihydrochloride
High affinity H3 receptor antagonist
2034 ROS 234 dioxalate
Potent H3 antagonist
4441 SEN 12333
Histamine H3 antagonist; α7 nAChR agonist
0644 Thioperamide
H3 antagonist and H4 inverse agonist
2493 VUF 5681 dihydrobromide
Potent H3 receptor silent antagonist
Ligand Sets
Cat.No.
Product Name / Activity
1876 Histamine H3 Receptor Tocriset™
Selection of 5 histamine H3 receptor ligands (Cat. Nos. 0729, 0569, 0752, 0779 and 0644)
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