Histamine H1 Receptors

More Information »Histamine H1 receptors are Gαq/11-protein-coupled receptors that mediate allergic responses. These receptors are expressed in a wide variety of tissues including the gastrointestinal tract, CNS, airway and vascular smooth muscle cells and endothelial cells.

Histamine H1 Receptor Products

Agonists
Cat.No.
Product Name / Activity
3545 Histamine dihydrochloride
Endogenous histamine receptor agonist
0646 HTMT dimaleate
H1 / H2 agonist
2478 2-Pyridylethylamine dihydrochloride
H1 receptor agonist
Antagonists
Cat.No.
Product Name / Activity
3489 Astemizole
Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker.
2577 Cetirizine dihydrochloride
Selective H1 antagonist
1453 Clemastine fumarate
H1 antagonist
5371 Clemizole hydrochloride
Histamine H1 antagonist; also TRPC5 blocker
5958 Desloratadine
High affinity H1 antagonist; anti-inflammatory.
1425 (S)-(+)-Dimethindene maleate
H1 antagonist. Also M2 muscarinic antagonist
3072 Diphenhydramine hydrochloride
H1 receptor antagonist
0508 Doxepin hydrochloride
Highly potent H1 antagonist. Also binds to H4 receptor
2429 Fexofenadine hydrochloride
H1 receptor antagonist; non-sedating antiallergic agent
0784 Ketotifen fumarate
H1 antagonist
1944 Loratidine
Peripheral H1 antagonist; antiallergic agent
4245 Meclizine dihydrochloride
H1 antagonist; human pregnane X receptor agonist
0660 Mepyramine maleate
Selective H1 inverse agonist
2018 Mirtazapine
Potent H1 antagonist. Also 5-HT2, 5-HT3 and α2-antagonist. Antidepressant
4241 Olopatadine hydrochloride
H1 antagonist; ocular antiallergic agent
3948 Terfenadine
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
0662 trans-Triprolidine hydrochloride
Standard H1 antagonist, highly potent
3996 Zotepine
H1 antagonist. Also 5-HT2A/D2 antagonist. Atypical antipsychotic
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