Dopamine transporters (DAT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain in areas of dopaminergic activity, including the striatum and substantia nigra. They provide rapid clearance of dopamine, adrenalin and noradrenalin from the synaptic cleft, terminating the neurotransmitter signal.
Dopamine transporters can also mediate an outward efflux and it has been suggested that inward and outward transport are independently regulated. Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. There is evidence to support the role of dopamine transporters in attention deficit disorder, bipolar disorder, clinical depression and alcoholism.
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Literature for Dopamine Transporters
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.Request copy | Download PDF | View all posters
Written by Anthony H.V. Schapira, this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. This poster also presents new and emerging therapeutic strategies to delay the onset and progress of PD. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
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