D1 and D5 Receptors

Supporting information

D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
D1 Human DRD1 NM_000794 P21728
Mouse Drd1a NM_010076 Q61616
Rat Drd1a NM_012546 P18901
D5 Human DRD5 NM_000798 P21918
Mouse Drd5 NM_013503 Q8BLD9
Rat Drd5 NM_012768 P25115

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