Glycine Receptors

Supporting information

Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.

Glycine receptors exist as pentameric proteins, homo-oligomers of the α isoforms (α1, α2, α3 or α4) or hetero-oligomers which also contain the β-subtype variant (β1) which is essential for targeting the receptor to the synapse. Glycine receptors contain an integral chloride channel, and have modulatory sites for anesthetics, neurosteroids, cannabinoids and ethanol. Disruption in glycine receptor expression or ion channel function can result in hyperekplexia, a rare neurological disorder.

To view external sources of pharmacological information for Glycine Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Glycine Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GLRα1 Human GLRA1 NM_000171 P23415
Mouse Glra1 NM_020492 Q64018
Rat Glra1 NM_013133 P07727
GLRα2 Human GLRA2 NM_002063 P23416
Mouse Glra2 NM_183427 Q7TNC8
Rat Glra2 NM_012568 P22771
View all Glycine Receptor Gene Data »

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