GABA Transporters

Supporting information

GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia.

While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons.

Some anticonvulsants have been reported to act upon the GABA transporters. There is evidence to suggest that GABA transporters are linked to epilepsy, affective disorders and schizophrenia.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GAT-1 Human SLC6A1 NM_003042 P30531
Mouse Slc6a1 NM_178703 P31648
Rat Slc6a1 NM_024371 P23978
GAT-2 Human SLC6A13 NM_016615 Q9NSD5
Mouse Slc6a12 NM_133661 P31651
Rat Slc6a13 NM_133623 P31646
View all GABA Transporter Gene Data »

Literature for GABA Transporters

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
GABA Receptors Scientific Review

A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

Request copy | Download PDF | View all reviews
GABA Receptors Scientific Review
Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.

Request copy | Download PDF | View all posters
Addiction Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

Request copy | View all posters
Schizophrenia Life Science Poster

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GABA Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

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