GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia.
While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for phosphorylation. A vesicular transporter (VGAT) has also been identified. This member of the SCL32 family is both structurally and functionally distinct, containing 10-TM domains and being found in GABAergic and glycinergic neurons.View all products for GABA Transporters »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
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Literature for GABA Transporters
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.Request copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
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