GABAA-ρ Receptors

Supporting information

GABAA-ρ receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. They were previously known as GABAC receptors, but IUPHAR now considers them to be a subtype of GABAA receptors.

GABAA-ρ receptors differ from other GABAA receptors in pharmacology, physiology and biochemistry. Most GABAA receptors are heteromeric pentamers, generally comprising two α, two β and one other subunit, whereas GABAA-ρ receptors are homomeric pentamers assembled from ρ subunits only. There are three known ρ subunits, ρ1, ρ2, ρ3, and while heteromeric oligomers of these subunits have been proposed, only one receptor, made up solely of ρ1 subunits has been definitively identified to date. The resulting ion channel is not blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and selectively blocked by TPMPA. It is relatively insensitive to benzodiazepines, barbiturates and general anesthetics. In addition, the GABAA-ρ receptor has a longer channel opening time and is slower to desensitize. These receptors are expressed in various brain regions and particularly high levels are found in the retina and cerebellum.

To view external sources of pharmacological information for GABAA-ρ Receptors, please click here: IUPHAR Receptor Code

View all products for GABAA-ρ Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ρ1 Human GABRR1 NM_002042 P24046
Mouse Gabrr1 NP_032101 P56475
Rat Gabrr1 NM_017291 P50572
ρ2 Human GABRR2 NP_032102 P28476
Mouse Gabrr2 NM_008076 P56476
Rat Gabrr2 NM_017292 P47742
View all GABAA-ρ Receptor Gene Data »

Literature for GABAA-ρ Receptors

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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GABA Receptors Scientific Review

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GABA Scientific Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

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