GABAB Receptors

Supporting information

GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory effects of GABA alongside ionotropic GABAA and GABAA-ρ receptors. They exist as heterodimers of GABAB1 and GABAB2 subunits and the presence of both subunits is required for receptor function.

When GABAB1 is expressed alone it is non-functional and is not transported to the cell membrane. This subunit is responsible for binding GABA, and the GABAB2 subunit interacts with the G protein. The two subunits interact allosterically: GABAB1 increases coupling of GABAB2 to G proteins and GABAB2 increases agonist binding to GABAB1. GABAB receptors are coupled to Ca2+ and K+ channels.

To view external sources of pharmacological information for GABAB Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GABAB1 Human GABBR1 NM_021905 Q9UBS5
Mouse Gabbr1 NM_019439 Q9WV18
Rat Gabbr1 NM_031028 Q9Z0U4
GABAB2 Human GABBR2 NM_005458 O75899
Mouse Gabbr2 NM_001081141 Q80T41
Rat Gabbr2 NM_031802 O88871

Literature for GABAB Receptors

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