GABAA receptors are members of the Cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of GABA alongside GABAB and GABAA-ρ receptors. They are heteromeric pentamers, consisting of five subunits belonging to different families (α1-6, β1-3, γ1-3, δ, π, ε, θ).
The most abundant GABAA receptor in the mammalian brain consists of two copies each of subunits α1 and β2 with a single γ2 subunit. GABAA receptors contain an integral chloride channel, and have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.
To view external sources of pharmacological information for GABAA Receptors, please click here: IUPHAR Receptor CodeView all products for GABAA Receptors »
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Literature for GABAA Receptors
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.Request copy | Download PDF | View all posters
Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
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