GABAA Receptors

Supporting information

GABAA receptors are members of the Cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of GABA alongside GABAB and GABAA-ρ receptors. They are heteromeric pentamers, consisting of five subunits belonging to different families (α1-6, β1-3, γ1-3, δ, π, ε, θ).

The most abundant GABAA receptor in the mammalian brain consists of two copies each of subunits α1 and β2 with a single γ2 subunit. GABAA receptors contain an integral chloride channel, and have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.

To view external sources of pharmacological information for GABAA Receptors, please click here: IUPHAR Receptor Code

View all products for GABAA Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GABAA α1 Human GABRA1 NM_001127645 P14867
Mouse Gabra1 NM_010250 P62812
Rat Gabra1 NM_183326 P62813
GABAA α2 Human GABRA2 NM_000807 P47869
Mouse Gabra2 NM_008066 P26048
Rat Gabra2 L08491 P23576
View all GABAA Receptor Gene Data »

Literature for GABAA Receptors

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
GABA Receptors Scientific Review

A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

Request copy | Download PDF | View all reviews
GABA Receptors Scientific Review
Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.

Request copy | Download PDF | View all posters
Addiction Life Science Poster
Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.

Request copy | Download PDF | View all posters
Pain Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

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Schizophrenia Life Science Poster

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GABA Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

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Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

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