Glutamate (Metabotropic) Group III Receptors

Supporting information

Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. mGlu group III receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in spatial learning and memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8 receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.

To view external sources of pharmacological information for Glutamate (Metabotropic) Group III Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu4 Human GRM4 NM_000841 Q14833
Mouse Grm4 NM_001013385 Q68EF4
Rat Grm4 NM_022666 P31423
mGlu6 Human GRM6 NM_000843 O15303
Mouse Grm6 BC034118 Q5NCH9
Rat Grm6 NM_022920 P35349
View all Glutamate (Metabotropic) Group III Receptor Gene Data »

Literature for Glutamate (Metabotropic) Group III Receptors

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