Glutamate (Metabotropic) Group II Receptors

Supporting information

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

To view external sources of pharmacological information for Glutamate (Metabotropic) Group II Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu2 Human GRM2 NM_000839 Q14416
Mouse Grm2 AK034263 Q14BI2
Rat Grm2 NM_001105711 P31421
mGlu3 Human GRM3 NM_000840 Q14832
Mouse Grm3 NM_181850 Q9QYS2
Rat Grm3 NM_001105712 P31422

Literature for Glutamate (Metabotropic) Group II Receptors

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