Glutamate (Metabotropic) Group II Receptors

More Information »Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Glutamate (Metabotropic) Group II Receptor Products

Agonists
Cat.No.
Product Name / Activity
0284 (1S,3R)-ACPD
Group II/group I mGlu agonist
0186 cis-ACPD
Selective group II agonist. Also potent NMDA agonist
0187 (±)-trans-ACPD
Group II/group I mGlu agonist
1208 (2R,4R)-APDC
Highly selective group II agonist
0329 (S)-3-Carboxy-4-hydroxyphenylglycine
Selective group II mGlu agonist, also group I mGlu antagonist
0320 (S)-4-Carboxy-3-hydroxyphenylglycine
Group II agonist/group I antagonist
0323 (S)-4-Carboxyphenylglycine
Group I mGlu antagonist/weak group II agonist
0333 L-CCG-l
Potent group II mGlu agonist
0975 DCG IV
Very potent, selective group II mGlu agonist. Also NMDA agonist
3246 LY 354740
Potent and highly selective group II mGlu agonist
2453 LY 379268
Highly selective group II mGlu agonist
5064 LY 379268 disodium salt
Sodium salt of LY 379268 (Cat. No. 2453); selective group II mGlu receptor agonist
3272 (±)-LY 395756
Mixed mGlu2 agonist/ mGlu3 antagonist
0711 MAP4
Potent group II mGlu agonist. Also specific group III mGlu antagonist
3332 NPEC-caged-LY 379268
Caged group II mGlu receptor agonist
0391 Spaglumic acid
Selective mGlu3 agonist
Antagonists
Cat.No.
Product Name / Activity
1073 (RS)-APICA
Selective group II antagonist
1009 E4CPG
Group II/group I mGlu antagonist
0971 EGLU
Highly selective group II mGlu antagonist
1209 LY 341495
Highly potent, selective group II antagonist
4062 LY 341495 disodium salt
Disodium salt of LY 341495 (Cat. No. 1209)
3696 (RS)-MCPG disodium salt
Non-selective mGlu antagonist
0336 (RS)-MCPG
Non-selective mGlu antagonist
0337 (S)-MCPG
Non-selective mGlu antagonist. Active isomer of Cat. No. 0336
0854 MSPG
Group II/group III mGlu antagonist
0855 MTPG
Group II/group III mGlu antagonist. More selective for group II than group III
2913 Ro 64-5229
Selective, non-competitive mGlu2 antagonist
Modulators
Cat.No.
Product Name / Activity
4048 BINA
Selective positive allosteric modulator of mGlu2
3949 CBiPES hydrochloride
Positive allosteric modulator of mGlu2
4969 LY 2389575 hydrochloride
Selective negative allosteric modulator of mGlu3
3283 LY 487379 hydrochloride
Positive allosteric modulator selective for mGlu2
4976 ML 289
Selective negative allosteric modulator of mGlu3
4982 ML 337
Selective negative allosteric modulator of mGlu3
4388 MNI 137
Selective negative allosteric modulator of group II mGlu receptors
Activators
Cat.No.
Product Name / Activity
4120 Xanthurenic acid
Selectively activates group II mGlu receptors
Ligand Sets
Cat.No.
Product Name / Activity
1827 Group II mGlu Receptor Tocriset™
Selection of 5 group II mGlu receptor ligands (Cat. Nos. 1208, 0975, 1209, 0971 and 0337)
1829 Mixed mGlu Receptor Tocriset™
Selection of 5 mixed mGlu receptor ligands (Cat. Nos. 0805, 0975, 0103, 0337 and 1209)
Other
Cat.No.
Product Name / Activity
4936 Clozapine N-oxide
Activator of muscarinic DREAADs
Related Categories

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

mGlu Receptors Review

Written by Francine Acher

Metabotropic Glutamate Receptors Scientific Review

Our Metabotropic Glutamate Receptor review gives an overview of the pharmacological ligands used to study the mGlu receptors . Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

divider line

Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands