Glutamate (Metabotropic) Group I Receptors

Supporting information

Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu1 and mGlu5. Group I mGluRs are coupled to Gq/11, which activates phospholipase C. They are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing conductance, causing more glutamate to be released from the presynaptic cell. They can also increase inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and modulate voltage-dependent calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG), allowing their function to be isolated. The human genes for mGluR1 and mGluR5 receptors have been localized to chromosomes 6 (6q24) and 11 (11q14.3) respectively.

To view external sources of pharmacological information for Glutamate (Metabotropic) Group I Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
mGlu1 Human GRM1 NM_000838 Q13255
Mouse Grm1 NM_001114333 P97772
Rat Grm1 NM_017011 P23385
mGlu5 Human GRM5 NM_000842 P41594
Mouse Grm5 NM_001081414 Q3UVX5
Rat Grm5 NM_017012 P31424

Literature for Glutamate (Metabotropic) Group I Receptors

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