AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission in the CNS and play a key role in hippocampal synaptic long-term potentiation (LTP) and depression (LTD).
AMPA receptors consist of GluR1-4 subunits which assemble as homomers or heteromers to form functional AMPA receptors. The subunit composition determines the physiological properties of AMPA receptors: those containing the GluR2 subunit show low permeability to Ca2+ whereas those lacking this subunit show high Ca2+ permeability.
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Literature for AMPA Receptors
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Written by Prof David Nutt, this poster summarizes the brain circuits associated with addiction and outlines the main classes of addictive drugs and neurotransmitter systems affected by them. Compounds available from Tocris for addiction research are listed.Request copy | Download PDF | View all posters
Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Phil Skolnick, Piotr Popik and Ramon Trullas and updated in 2015, this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by E. Clea Warburton and Zafar Bashir, this poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression. The role of different neurotransmitters involved in recognition memory and synaptic plasticity are also summarized. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Anthony H.V. Schapira, this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. This poster also presents new and emerging therapeutic strategies to delay the onset and progress of PD. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
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