Glutamate (EAAT) Transporters

Supporting information

Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).

Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle.

Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.

To view external sources of pharmacological information for Glutamate (EAAT) Transporters, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
EAAT1 Human SLC1A3 NM_004172 P43003
Mouse Slc1a3 NM_148938 P56564
Rat Slc1a3 NM_019225 P24942
EAAT2 Human SLC1A2 NM_004171 P43004
Mouse Slc1a2 NM_001077514 P43006
Rat Slc1a2 NM_017215 Q91ZA9
View all Glutamate Transporter Gene Data »

Literature for Glutamate (EAAT) Transporters

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
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Neurodegeneration Product Guide
Huntington's Disease Life Science Poster

Written by Annalena Wieland and Nicholas Allen, this poster summarizes the medium spiny neuron intracellular signaling pathways implicated in the pathology of Huntington's disease (HD), as well as highlighting the use of iPSCs for HD modeling. Compounds available from Tocris are listed

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Huntington's Disease Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

Request copy | View all posters
Schizophrenia Life Science Poster

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Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

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Huntington's Disease: Pathophysiology and Clinical Prospects

Huntington's Disease Life Science Poster

Our Huntington's Disease (HD) poster summarizes the medium spiny neuron intracellular signaling pathways implicated in the pathology of HD. Request copy or view PDF today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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