Glutamate (EAAT) Transporters
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle.
Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.
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Literature for Glutamate (EAAT) Transporters
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Written by Annalena Wieland and Nicholas Allen, this poster summarizes the medium spiny neuron intracellular signaling pathways implicated in the pathology of Huntington's disease (HD), as well as highlighting the use of iPSCs for HD modeling. Compounds available from Tocris are listedRequest copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
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