Glutamate (EAAT) Transporters

More Information »Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Glutamate Transporter Products

Product Name / Activity
0271 cis-ACBD
Potent, selective L-glutamate uptake inhibitor
0332 L-CCG-lll
Potent, competitive glutamate uptake inhibitor
0846 Chicago Sky Blue 6B
Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
3697 7-Chlorokynurenic acid sodium salt
Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
0237 7-Chlorokynurenic acid
Potent competitive inhibitor of L-glutamate uptake
0111 Dihydrokainic acid
EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
0845 Evans Blue tetrasodium salt
Potent inhibitor of L-glutamate uptake into synaptic vesicles
2217 (±)-HIP-A
Potent, non-competitive EAAT inhibitor
2218 (±)-HIP-B
Potent, non-competitive EAAT inhibitor
0183 L-(-)-threo-3-Hydroxyaspartic acid
Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
0811 (±)-threo-3-Methylglutamic acid
EAAT2 and EAAT4 blocker
0973 MPDC
Potent inhibitor of L-glutamate uptake. Less activity as a substrate compared to its parent compound, L-trans-2,4-PDC (Cat. No. 0298)
0298 L-trans-2,4-PDC
Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
0903 SYM 2081
Inhibits EAAT2. Also kainate receptor agonist
1223 DL-TBOA
Selective non-transportable inhibitor of EAATs
High affinity EAAT1 and EAAT2 blocker
3490 UCPH 101
Selective non-substrate EAAT1 inhibitor
2652 WAY 213613
Potent, non-substrate EAAT2 inhibitor
Ligand Sets
Product Name / Activity
1830 Excitatory Amino Acid Transporter Inhibitor Tocriset™
Selection of 5 EAAT inhibitors (Cat. Nos. 0183, 0298, 1223, 0111 and 0903)
Product Name / Activity
3732 Ceftriaxone disodium salt
Neuroprotective; increases EAAT2 expression and activity
5082 LDN 212320
Increases EAAT2 expression; neuroprotective
2277 MNI-caged-D-aspartate
Caged D-aspartate; EAAT substrate
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