Caspases

More Information »Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.

Caspase Products

Inhibitors
Cat.No.
Product Name / Activity
2172 AZ 10417808
Selective non-peptide caspase-3 inhibitor
2166 Z-DEVD-FMK
Cell-permeable, irreversible caspase-3 inhibitor
2168 Z-DQMD-FMK
Caspase-3 inhibitor
2163 Z-VAD-FMK
Cell-permeable, irreversible caspase inhibitor
2165 Z-VDVAD-FMK
Irreversible caspase-2 inhibitor
Substrates
Cat.No.
Product Name / Activity
1576 Ac-IEPD-AFC
Fluorogenic granzyme B substrate
1575 Ac-LEHD-AFC
Fluorogenic caspase substrate
Activators
Cat.No.
Product Name / Activity
2251 Cisplatin
Potent pro-apoptotic anticancer agent; activates caspase-3
3590 Gambogic acid
Apoptosis inducer. Activates caspases
2581 PAC 1
Activator of procaspase-3; pro-apoptotic
1758 PETCM
Activator of caspase-3
Other
Cat.No.
Product Name / Activity
2098 Apoptosis Activator 2
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
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