Adrenergic α1 Receptors

Supporting information

Adrenergic α1 receptors (α1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes α2A, α2B, α2C, β1, β2 and β3. The adrenergic α1 receptors are further divided into three subtypes: α1A, α1B and α1D receptors. α1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth α1 receptor subtype has been postulated and is designated as α1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the α1A subtype.

To view external sources of pharmacological information for Adrenergic α1 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α1A Human ADRA1A NM_033303 P35348
Mouse Adra1a NM_013461 P97718
Rat Adra1a NM_017191 P43140
α1B Human ADRA1B NM_000679 P35368
Mouse Adra1b NM_007416 P97717
Rat Adra1b NM_016991 P15823
View all α1 Gene Data »

Literature for Adrenergic α1 Receptors

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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Cardiovascular Research Product Guide
GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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GPCR Product Listing
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster
Depression Life Science Poster

Written by Phil Skolnick, Piotr Popik and Ramon Trullas and updated in 2015, this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs. Compounds available from Tocris are listed.

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Depression Life Science Poster

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

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