Adrenergic Transporters

Supporting information

Adrenergic transporters (NET) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) widely distributed throughout the brain within noradrenergic neuronal plasma membranes. They are responsible for the re-uptake of adrenalin, noradrenalin and (to a lesser extent) dopamine from the synaptic cleft back into vesicles for storage until later use, resulting in the termination of neurotransmitter action.

Adrenergic transporters contain the following structural motifs: 12-TM domains, extracellular loops, cytoplasmic C- and N-termini and putative phosphorylation sites. A role for NETs has been proposed in attention deficit disorder, substance abuse, neurodegenerative disorders and clinical depression.

To view external sources of pharmacological information for Adrenergic Transporters, please click here: BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human SLC6A2 NM_001043 P23975
Mouse Slc6a2 NM_009209 O55192
Rat Slc6a2 NM_031343 Q63380

Literature for Adrenergic Transporters

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